It means 3,033 patients have now died from Covid-19 in the region's hospitals since the pandemic began.
A total of 733 have died with the virus in the region's care homes.
A further 361 patients died in hospitals across England in figures announced on Wednesday, taking the country's hospital death toll to 35,324. It included 68 in the Midlands region.
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Seven deaths were reported at the Walsall Healthcare NHS Trust, which runs Walsall Manor Hospital, where the total increased to 277.
A further six deaths were recorded at the University Hospitals of North Midlands NHS Foundation Trust, which runs County Hospital in Stafford and the Royal Stoke University Hospital, bringing the trust’s death toll to 454.
Three deaths were reported at the Sandwell and West Birmingham Hospitals NHS Trust, which runs Sandwell General and City hospitals, where the toll increased to 455.
At the Royal Wolverhampton NHS Trust, which runs New Cross and Cannock Chase hospitals, a further three deaths were recorded – where the death toll now stands at 319.
And three deaths were confirmed at the University Hospitals Birmingham NHS Foundation Trust, which runs Queen Elizabeth, Heartlands, Good Hope and Solihull hospitals, where the total rose to 1,147.
No new deaths were announced at the Dudley Group NHS Foundation Trust, which runs Russells Hall Hospital, where the death toll remains at 304.
A spokesman for NHS England said: "A further 361 people, who tested positive for coronavirus (Covid-19) have died, bringing the total number of confirmed reported deaths in hospitals in England to 35,324.
"Patients were aged between 43 and 102 years old. All except 20 – aged between 58 and 95 years old – had known underlying health conditions.
"Date of death ranges from October 13 to November 10.
"Their families have been informed."