One patient had died in Wolverhampton, and another three in Birmingham, the latest figures from NHS England have shown.
It means the death toll at hospitals across the Black Country, Birmingham and Staffordshire is now at 2,657.
On top of this, 705 people have died in the region's care homes after contracting Covid-19.
No other deaths were confirmed at hospital trusts in Sandwell, Dudley, Walsall or Staffordshire today.
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In the latest figures from NHS England, it was reported that one person has died at the Royal Wolverhampton NHS Trust, which runs New Cross and Cannock Chase hospitals, taking the death toll to 296.
And three patients have died at the University Hospitals Birmingham NHS Trust, where the death toll is now at 1,029.
At Sandwell and West Birmingham NHS Trust, which runs Sandwell and City hospitals, the death toll stands at 397.
Over at the University Hospitals of North Midlands NHS Trust, which runs Stafford County and Stoke Royal hospitals, a total of 363 people have died after contracting coronavirus.
A total of 232 people have died at the Walsall Healthcare NHS Trust, which runs Walsall Manor Hospital.
And at Russell's Hall Hospital in Dudley, the total remains at 269.
A further 82 people, who tested positive for Covid-19 have died at hospitals across England, bringing the total number of confirmed reported deaths to 30,825.
Patients were aged between 35 and 97 years old. All except eight – aged between 49 and 94 – had known underlying health conditions.
Date of death ranges from October 2 to October 15, with the majority being on or after October 14.
Their families have been informed.