The latest NHS figures take the total death toll in hospitals across the region and in Staffordshire to 2,602.
One person died at Sandwell and West Birmingham NHS Trust, and another at University Hospitals Birmingham NHS Foundation Trust. Both patients died on Saturday.
The UK-death toll, which includes deaths in and out of hospital, increased by 13 to 42,001 today with all of these deaths in England.
Ten more deaths were announced in English hospitals by the NHS, with the patients aged between 60 and 97. All had known underlying health conditions.
The date of death ranged from September 24 to 27.
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At University Hospitals Birmingham, which runs which runs the Queen Elizabeth, Good Hope, Heartlands and Solihull hospitals, the death toll now stands at 1,002.
And at Sandwell and West Birmingham, which runs City and Sandwell General hospitals, 390 people have now died.
Elsewhere in the region, 266 people have died at Dudley Group NHS Foundation Trust, which runs Russells Hall Hospital.
At the Royal Wolverhampton NHS Trust, which runs New Cross and Cannock Chase hospitals, a total of 288 Covid-19 patients have died.
Meanwhile 230 people have died at Walsall Healthcare NHS Trust, which runs Walsall Manor, but no patients have died with Covid-19 at the Manor since July 9.
In Staffordshire, 355 people have died at the University Hospitals of North Midlands NHS Trust which runs the major hospitals in Stafford and Stoke.
A further 701 coronavirus deaths have been reported across care homes in the Black Country, Birmingham or Staffordshire.
Of these, 71 have been in Wolverhampton, 99 in Walsall, 59 in Dudley, 50 in Sandwell, 193 in Birmingham and 229 in Staffordshire.
The latest care home death happened on September 14 in Wolverhampton.