Matthew Babb, 33, died when the van he was driving crashed on Newport Road in Gnosall at 3.10am on Sunday, Staffordshire Police said.
A second man, also 33, survived and was taken to Royal Stoke University Hospital with a shoulder injury but has since been discharged.
Mr Babb's family have been informed and are being supported by specially-trained officers.
Both Mr Babb and the second man involved in the crash are from the Stafford area.
No other vehicles are thought to have been involved in the crash.
Police are investigating and have asked anyone with information to come forward.
A Staffordshire Police spokesman said: "Officers were called to Newport Road (the A518) at 3.10am on Sunday morning to a report of a single-vehicle collision involving a grey Vauxhall Combo van.
"Sadly, a man was pronounced dead at the scene. He has been formally identified as 33-year-old Matthew Babb, from the Stafford area.
"Witnesses who may have seen the vehicle before the collision or anyone with relevant dashcam footage is asked to message Staffordshire Police on Facebook or Twitter quoting incident number 90 of 29 August or call 101."
A West Midlands Ambulance Service spokeswoman said: "One man has died and another has suffered multiple injuries after a van crashed on Newport Road in Gnosall in the early hours of Sunday morning.
"An ambulance and two paramedic officers attended the scene after a 999 call at 3.13am. On arrival, ambulance staff found a badly damaged van which had overturned.
"Sadly, the man driving had suffered very serious injuries and was confirmed deceased at the scene. The second man was treated for multiple injuries and was taken to the major trauma centre at Royal Stoke University Hospital for further assessment and treatment.”