Staffordshire Police said they were called at 1.25am on Friday to reports of the victim being seriously injured on Bingley Avenue.
Despite the efforts of the emergency services, the woman died at the scene.
The force said a man from Tamworth was in hospital receiving treatment.
Specially trained officers were supporting the woman's family, police added.
The force have urged anyone with any information to message them on Facebook or Twitter quoting incident number 11 of November 20, call 101 or contact Crimestoppers anonymously on 0800 555 111.