Officers spoke to the 24-year-old who wasn't wearing a mask when they were on patrol earlier today, West Midlands Police said.
But she refused and was arrested for a public order matter.
A spokesman for the force said: “Officers were on patrol at Wolverhampton Bus Station in Pipers Row this morning when they spoke to a woman who wasn’t wearing a mask.
“She was spoken to about the legal requirement to wear a face covering on public transport and at transport hubs in order to limit the spread of coronavirus.
“The woman refused and acted aggressively towards officers.
“A 24-year-old woman of no fixed address was arrested for a public order matter."