Two men and a woman were arrested in the West Midlands on Thursday as part of a national police operation into drugs supply and money laundering.
A 27-year-old man and 24-year-old woman travelling together were stopped by Central Motorway Police Group officers at Junction 10 of the M6 near Wolverhampton.
The woman had £2,700 cash on her and a further £30,000 was found in the car's glovebox, the National Crime Agency said,
Meanwhile officers from West Mercia Police stopped a second car near Junction 5 of the M5 at Castle Bromwich, finding another £30,000 cash in the boot.
A 32-year-old man was arrested.
All three were arrested on suspicion of conspiracy to supply drugs and money laundering and remained in custody for questioning on Friday.
Jim Cook, National Crime Agency operations manager, said: "Seizing cash has a major impact on criminal networks involved in drug trafficking and prevents them from reinvesting their profits in criminality.
“Thanks to the support of our the Central Motorway Police Group and West Mercia Police we have what we believe is criminal cash. We will continue to work with partners to protect the public.”