Officers searched a home on Park Avenue at about 9am on Thursday and found drugs believed to be cannabis, heroin and crack were found.
A lock knife, scales and mobile phones were also found and seized.
The pair were arrested as part of the on-going Operation Disrupt, which aims to crack down on criminal activity across Staffordshire.
A 20-year-old man from Derby was arrested on suspicion of being concerned in drugs, possession of an offensive weapon and possession of a controlled drug.
A 39-year-old man from Uttoxeter was arrested on suspicion of possession with intent to supply. They remain in custody.
Chief Inspector Jason Nadin, commander for East Staffordshire, said: “This intelligence-led operation was carried out as part of a proactive policing investigation to tackle criminals who are causing the most harm to communities across Staffordshire.
“We will continue to disrupt crime in the area and I would ask anyone concerned about drugs or anyone with information to call 101.”