Police are appealing for information after two Staffordshire Bull Terriers were taken along with other items during a break-in at the house in New Street, Tipton.
The youngest puppy has been recovered but West Midlands Police is now appealing for the safe return of his 12-week-old sister Diamond.
The young pup, who is micro-chipped and pure blue with a small white patch on her chest area, was taken on November 27.
A force spokesperson said: "If you have any information about her whereabouts, or have seen a picture of her being sold online, please do not hesitate to contact us.
"We would love to be able to reunite Diamond with her family before Christmas."
Anyone with information is asked to call 101 anytime or contact Crimestoppers anonymously on 0800 555 111 quoting crime reference 20SW/277359V/18.