The Kingswinford Charity Truck Convoy, which is in its fifth year, began on Saturday afternoon and saw truckers from all over the West Midlands attend.
The stream of trucks travelled from Wolverhampton Road Holiday Inn, at junction 10 of the M6, before going through through Bilston, Dudley and finishing at Kingswinford.
The aim of the convoy event was to raise awareness of organ donation and raise money for Birmingham's Queen Elizabeth Hospital (QE).
A previous truck show held in Stourport earlier this year has already raised more than £4,000 for the hospital.
The cause is particularly close to the organiser's heart, as his wife underwent a life-changing liver transplant at the QE on Christmas Day in 2006.
Now however, the organ is beginning to fail for the mother-of-four and grandmother-of-three.
Andrew Day, aged 44, of Dudley said: "When my wife Rachel, 42, had her transplant, it changed her life.
"The quality of life she had back was amazing.
"I don't think people realise until it happens to them how important being signed up as an organ donor is.
"For us now, it's a case of wanting to raise awareness of it and try and find someone who can help her again, because it's not looking too good."
The former lorry driver, who now works in a transport office so he can be at home more frequently, supports the idea of an opt-out organ donation scheme.
He said: "I think there has been a lot of debate recently around automatically being put on the organ donation register and having to opt out afterwards.
"I would really support this because I know it's not something that people really think about until it happens close to home. If you can help someone and give them the gift of life, what more can you do?"