KFC is currently working on its fourth site on Bushbury Road in Bushbury, Wolverhampton.
It replaced the former Bushbury Working Mens' Club which was demolished to make way for the takeaway outlet.
It already has locations in the city centre, Penn and Bentley Bridge in Wednesfield.
Officials have now revealed that more than 300 have applied for the vacancies.
A spokesperson for KFC said: "We were been blown away by interest for a job at our new restaurant in Bushbury, interviewing over 300 people in just three days. The hard part was whittling down the number of great candidates to fill the 50 spaces, but we're very happy with the people we've hired."
The restaurant firm added: "Everyone is now looking forward to welcoming local residents to the store when we open in mid-April."
KFC would be a boost to that area of Bushbury after the former Strykers Bowling Alley, which had been opposite was destroyed by fire in December. The popular entertainment venue then had to be bulldozed through safety fears.