The male rider, believed to be in his early 20s, was pronounced dead at the scene of the crash on the A5 Watling Street despite the efforts of paramedics who fought to save him.
The Midlands Air Ambulance from Cosford was dispatched to the scene, as well as an advanced community paramedic, paramedic area support officer and ambulance crew following the crash at around 4.20pm yesterday.
Police closed a stretch of the A5 between Hednesford Road and Brownhills Parade following the crash. Motorists faced lengthy tailbacks during rush hour and police urged drivers to avoid the area. West Midlands Ambulance Service spokesman Chris Kowalik said: "Crews at the scene performed advanced life support techniques to the motorcyclist and tried to resuscitate him. Sadly, despite those best efforts, he was confirmed dead at the scene."
A resident who lives along Watling Street, who did not want to be named, said: "It happened around 4.20pm. We heard the police and ambulances arrive and the traffic was all backed up on the other side of the road.
"The air ambulance landed on Brownhills Common and at the scene we could see them pumping his chest for a long time."
It is the latest smash on the A5 in Brownhills. In June, three cars were involved in a crash, causing tailbacks for rush hour drivers.
Police had to close the road near The Crown pub.
A black Land Rover, a Renault Megane and a grey Seat were involved, although no one was reported to have been injured.
Meanwhile, a police officer and his PCSO colleague were taken to hospital after a crash on the A5 in February.
The police car was involved in a smash with a Ford B-Max.
West Midlands Police said investigations into the latest smash were ongoing and appealed for anyone who witnessed the collision to contact the Collision Investigation Unit on 101.