TJ Hughes in Wolverhampton, which employs almost 90 people, is closing down.
Yellow signs have been put up outside the branch in the Mander Centre telling customers "store closing down" and "everything must go."
Similar signs have also gone up at TJ Hughes in Walsall and Kidderminster.
The troubled department store went into administration last month putting more than 4,000 jobs at risk nationally.
It is believed the shops will start to close as soon as the last of the stock is sold, which is believed to be within three to four weeks.
Administrator Ernst & Young added today the business was still trading as a going concern and it was still trying to find a buyer.
The Wolverhampton shop, which is home to 87 workers, is the largest unit in the Mander Centre.
A total of 42 people are employed at the Walsall branch and 38 in Kidderminster.
The news comes just days after the shock closure of TJ Hughes' distribution centre in Liverpool.
More than 100 workers were sacked immediately.