A father and grandmother to two young children have been arrested on suspicion of kidnap and attempted child abduction.
Police had appealed for information after two-year-old Na'llah Khan and her 10-month-old brother Sulailman Khan were taken from a hotel room in Stoke-on-Trent on Friday.
But the children were found safe and well in a guest house near Derby town centre at around 7pm today. Their mother and wider family have been informed and the youngsters are being supported by specially trained officers before being re-united, police in Staffordshire said.
The children's father, Saleem Tahir, 40, and 67-year-old grandmother, Denise Smith-Sellars, both from Nottingham have been arrested on suspicion of kidnap and attempted child abduction.
The pair have been taken into custody where they will be interviewed by detectives.
A spokesman said: "Staffordshire Police would like to take this opportunity to thank the public, the media and colleagues from a number of forces in the region for their assistance and support."