A 22-year-old man is believed to have been attacked moments after stepping off a bus while coming home from work.
Part of Dudley Road East in Tividale, near Oldbury, is closed today after the man was found injured in the road after midnight.
It is thought an off-duty police officer found the man, who is not being named at this stage, with serious injuries and called for paramedics.
His family told the Express & Star he has bleeding on the brain, a fractured skull and has had his teeth knocked out.
He was today being treated in Dudley's Russells Halls Hospital.
The exact circumstances of the incident are still being investigated at this stage.
But the man's family have launched an appeal for information to help discover what happened.
They said he was getting off the number 87 bus moments before the attack happened.
A 500-yard section of Dudley Road East was shut by officers from West Midlands Police.
Residents say the cordon was put in place around 9am to close the road between the junction of Roway Lane and Salop Street.
Officers at the scene would only say they are dealing with a 'police incident' at this stage.
A police photographer has been taking pictures including of drains near a bus shelter in the road.
One family member, who also asked not to be named at this stage, said: "We are still in shock but we just want to get the word out there to try and find out what has happened."