The Government-commissioned review of aviation capacity must rule out expansion of Heathrow and end the "ludicrous" uncertainty about the cap ital's airports, London Mayor Boris Johnson will tell business leaders.
Mr Johnson said that the Airports Commission, led by Sir Howard Davies, should acknowledge in its interim report next month that it is "politically and environmentally impossible" to add extra runways at Heathrow and the focus should be on a new hub airport to the east of the capital instead.
In his speech to the CBI he will call for Heathrow to be bulldozed and replaced by housing, and will also dismiss the prospect of an extra runway at Gatwick solving the capacity problem.
Only a new airport at one of three sites - the "Boris island" in the Thames estuary, an enlarged Stansted or the Isle of Grain development - will meet the needs of London and the UK, Mr Johnson believes.
Ahead of the speech Mr Johnson said: "When Howard Davies publishes his interim report next month he must put an end to this unforgivable, baffling and ludicrous uncertainty and explicitly rule out any expansion at Heathrow.
"The 480,000 air traffic movements cap should not and cannot be lifted in the short, medium or long term. If Heathrow expansion is politically and environmentally impossible, which it is, we need to stop dithering, decide now on a hub airport solution to the east, and get on with it.
"I hope a man as wise as Howard Davies gets that, and rules out Heathrow now before it is too late."
He said it was "utterly bewildering" to find British architects and engineers building hub airports around the world " while the debate about how to do that in the UK meanders tardily onwards".
"It is time to stop dithering, assemble our finest engineers and build a multi-runway hub airport to the east of London. It is the only feasible location and the only solution that would be of long term benefit to our economy."
The Mayor will argue that other countries are benefiting from the UK's lack of capacity, with Heathrow now level pegging with Helsinki in Finland in terms of the number of Chinese destinations served.
He believes that the transport bill alone for adding a third runway to Heathrow would be £20 billion, and the total cost of expansion would be comparable to the construction of a new hub.
He will argue that the regeneration to the east of London would boost GDP by around £650 billion and the Heathrow site could be used to provide homes for 180,000 people.
Shadow chancellor Ed Balls called for the Davies Commission to publish its final report before the 2015 election following recommendations by Sir John Armitt in his Labour-commissioned review of infrastructure planning.
He said: "We welcome the Howard Davies review and it is Labour's view that it should report before the general election and not after. Under the Armitt plan, it would not have been possible to set up the Davies review without proper cross-party consultation, or kick the report into the next parliament.
"And if any future government then were to sit on the recommendations, the Armitt plan would give a clear remit to the independent commission to chivvy and chase."